Technical Data

007994
CAS Number
151519-50-5
Grade
Highly Purified
Molecular Formula
C₅₀H₇₇NO₁₃
Molecular Weight
900.15
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-70°C
7-O-Demethyl Rapamycin
7-O-Demethyl Cypher; 7-O-Demethyl Rapammune; 7-O-Demethyl Sirolimus

Rapamycin metabolite.

Synonyms
7-O-Demethyl Cypher; 7-O-Demethyl Rapammune; 7-O-Demethyl Sirolimus
Appearance
Supplied as a white to pale yellow solid
Molecular Formula
C₅₀H₇₇NO₁₃
Molecular Weight
900.15
Melting Point
>108ºC (dec.)
Solubility
Chloroform (Slightly), Methanol (Slightly)
Atmosphere
Inert Gas
Method for Determining Identity
Proton NMR (CDCl3)Spectroscopic and Mass Spectrometric Analysis
TLC Conditions
SiO2; Dichloromethane: Methanol: 9:1; Visualized with UV and KMnO4; Single spot, Rf=0.65
Elemental Analysis
Calculated: %C: 66.72, %H: 8.62, %N: 1.56
Storage and Stability
Long-term storage is recommended at -70°C. Stable for 6 months after receipt. Store under inert atmosphere. Caution: Hygroscopic.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
Source
Synthetic
Purity
~80%
Form
Supplied as a white to pale yellow solid
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Dickman, D., et al.: Bioorg. Med. Chem. Lett., 10, 1405 (2000). 2. Davis, D., et al.: Clin. Biochem., 33, 31 (2000). 3. Cummins, C., et al.: J. Pharmacol. Exper. Ther., 308, 143 (2004). 4. Scholer, A., et al.: Clin. Lab., 52, 325 (2006).
USBio References
No references available
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