Doramapimod

010951

CAS Number

285983-48-4

Grade

Highly Purified

Molecular Formula

C31H37N5O3

Molecular Weight

527.66

EU Commodity Code

38220090

Shipping Temp

Storage Temp

4°C

N-[3-(1,1-Dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]urea; BIRB 796BS; Birb 796;

Doramapimod is a highly potent inhibitor of p38 mitogen-activated protein kinase (MAPK). Doramapimod is a potential agent for the treatment of inflammatory diseases. Doramapimod blocks baseline and bortezomib-triggered upregulation of p38 MAPK and Hsp27 phosphorylation leading to enhanced cytotoxicity and caspase activation.

Form

Pale Beige Solid

Melting Point

136-139°C

Solubility

DMSO, Methanol

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References

Pargellis, C. et al.: Nat. Struct. Biol., 9, 268 (2002,); Kuma, Y. et al.: J. Biol. CHem., 280, 19472 (2005); Yasui, H. et al.: Br. J. Haematol., 136, 414 (2007);

USBio References

No references available

Technical Data