Technical Data

010967
CAS Number
24390-14-5
Grade
Highly Purified
Molecular Formula
C22H24N2O8·HCl·0.5C2H6O·0.5H2O
Molecular Weight
512.94
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
Doxycycline Hyclate
Doxycycline hydrochloride hemiethanolate hemihydrate; (4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide Hyclate

A synthetic derivative of oxytetracycline. Acts as a broad spectrum antibiotic and matrix metallo-proteinases (MMP) inhibitor. Useful in studies involving wound healing and tissue remodeling.

Synonyms
Doxycycline hydrochloride hemiethanolate hemihydrate; (4S,4aR,5S,5aR,6R,12aS)-4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,5,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide Hyclate
CAS Number
24390-14-5
Molecular Formula
C22H24N2O8·HCl·0.5C2H6O·0.5H2O
Molecular Weight
512.94
Appearance
Yellow crystalline powder
Purity
95-102% (anhydrous and ethanol free)
Melting Point
206-209°C (dec.)
Water
1.4-2.8%
Ethanol
4-6%
Specific Optical Rotation
As reported
Solubility
DMSO (~100mM) or H2O (~100mM), Methanol
Storage and Stability
Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Fabre, et al.: Chemotherapia, 11, 73 (1966), 2. Goldenthal, et al.: Toxicol. Appl. Pharmacol., 18, 185 (1971), 3. Polson, A.M., et al.: J. Periodontol., 68, 110 (1997).
USBio References
No references available
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