Technical Data

011189
CAS Number
51-43-4
Grade
Highly Purified
MDL Number
MFCD00002204
Molecular Formula
C9H13NO3
Molecular Weight
183.2
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C
L-(-)-Epinephrine
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol; (R)-Epinephrine; Renoform; Renostypticin; Adnephrine; Adrenal; Adrenalin; Adrenaline; l-Epinephrine; Levoepinephrine

Endogenous catcholamine with combined α-and β-agonist activity. Principal sympathomimetic hormone produced by the adrenal medulla. Bronchodilator; cardiostimulant; mydriatic; antiglaucoma. L-Adrenaline is a hormone that belongs to the group of nonsteroidal anti-inflammatory drugs. It is used in combination therapy for the treatment of asthma, chronic obstructive pulmonary disease and other respiratory diseases. L-Adrenaline has also been shown to increase blood pressure and heart rate. L-Adrenaline may interact with other medication such as cardiac glycosides and calcium channel blockers. L-Adrenaline is a potent vasoconstrictor that can cause primary pulmonary hypertension, which can lead to heart failure. The epinephrine binds to receptors on cells in the lungs, increasing bronchial secretions, which reduces the symptoms of anaphylaxis.

Synonyms
4-[(1R)-1-Hydroxy-2-(methylamino)ethyl]-1,2-benzenediol; (R)-Epinephrine; Renoform; Renostypticin; Adnephrine; Adrenal; Adrenalin; Adrenaline; l-Epinephrine; Levoepinephrine
CAS No
51-43-4
Molecular Formula
C9H13NO3
Molecular Weight
183.20
Appearance
White to off-white powder
Purity
≥98%
IR
Conforms to reference
Chiral Purity
≥97% (ee)
Melting Point
215°C (dec.)
Optical Rotation
[a]D20 = -50.0 to -53.5°
Other Enantiomer
≤3%
Epinephrine methoxy analog
≤ 0.1%
N-Benzylepinephrine
≤ 0.1%
N-Benzyl Adrenalone
≤ 0.1%
Any individual impurity
≤ 0.1%
Total impurities
≤ 0.5%
Norepinephrine
≤0.1%
Epinephrine Sulfonate
≤0.2%
Oxedrine
≤0.1%
Adrenalone
≤0.2%
Epinine
≤0.1%
Residue on Ignition
≤0.1%
Solubility
xxx
Storage and Stability
Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Malmejac, et al.: Physiol. Rev., 44, 186 (1964), Pohorecky, L.A., et al.: Pharmacol. Rev., 23, (1971), Hebert, P., et al.: J. Emerg. Med., 9, 487 (1991), McLean-Tooke, et al.: Br. Med. J., 327, 1332 (2003)
USBio References
No references available
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