011891
CAS Number
84633-29-4Grade
Highly PurifiedMolecular Formula
C₂₀H₂₄O₉Molecular Weight
408.4EU Commodity Code
38220090Shipping Temp
RTStorage Temp
-20°CEurycomanone
1,20-Epoxy-1,11,12,14,15-pentahydroxy-(1β,11β,12α,15β)-Picrasa-3,13(21)-diene-2,16-dione; NSC 339187; Pasakbumin A
Eurycomanone is known as a cytotoxic compound found in Eurycoma Longifolia Jack. Previous studies had noted its cytotoxic effects against various cancer cell lines. More recent research demonstrated the ability of Eurycomanone to suppress the expression of lung cancer cell tumor markers, prohibitin, annexin 1 and endoplasmic reticulum protein 28. Eurycomanone was shown to also exerts the ability to induce apoptosis through the up-regulation of p53 in human cervical carcinoma cells.
Molecular Formula
C₂₀H₂₄O₉
Melting Point
>220°C (dec.)
Solubility
DMSO (Slightly), Pyridine (Slightly, Sonicated)
Storage and Stability
Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Wong, P.F., et al.: Phytomed., 19, 138 (2012); Nurkhasanah, M., et al., Medunion Press., 4, 109 (2008); Zakaria, Y., et al.: Cancer Cell Intern., 9, (2009);USBio References
No references available