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014719 iCRT-14 CAS: 677331-12-3

Specifications
References
CAS Number
677331-12-3
Grade
Highly Purified
Molecular Formula
C21H17N3O2S
Molecular Weight
375.44
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
RT
5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione; iCRT 14; iCRT14;

A potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Studies suggest that it may directly influence the interaction between β-catenin and TCF4. It induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines.

References
Gonsalves, F.C. et al.: Proc. Natl. Acad. Sci. USA, 108, 5954 (2011); Watanabe, K. et al.: Proc. Natl. Acad. Sci. USA, 108, 5929 (2011);
USBio References
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