Myriocin

017930

CAS Number

35891-70-4

Grade

Highly Purified

Molecular Formula

C21H39NO6

Molecular Weight

401.54

EU Commodity Code

38220090

Shipping Temp

Storage Temp

(2S,3R,4R,6E)-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic Acid; [2S-(2R,3S,4S*,6E)]-2-Amino-3,4-dihydroxy-2-(hydroxymethyl)-14-oxo-6-eicosenoic Acid; (+)-Myriocin; ISP-I; NSC 177379; Thermozymocidin; (2S,3R,4R)-(E)-2-Amino-3,4-dihydroxy-2-hydroxymethyl-14-oxoeicos-6-enoic Acid;

Myriocin is a atypical amino acid and an antibiotic with potent immunosuppressant activity. Studies suggest that the immunosuppressant activity in the cytotoxic T-cell line CTTL-2 is due to apoptosis induction. Myriocin very potent inhibitor of serine palmitoyltransferase and thus blocks the synthesis ceramide, a precursor in sphingomyelin and glycosphingolipid biosynthesis. As a result Myriocin is a useful biochemical research tool for depleting cells of sphingolipids.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References

Miyake, Y., et al.: Biochem. Biophys. Res. Commun., 211, 396 (1995); Hidari, K.I.P.J. et al.: J. Biol. Chem., 271, 14636 (1996); Nakamura, S. et al.: J. Biol. Chem., 271, 1255 (1996); De Zélicourt, A. et al.: Planta 230, 1047 (2009);

USBio References

No references available

Technical Data