018024
CAS Number
7681-93-8Grade
Highly PurifiedMolecular Formula
C₃₃H₄₇NO₁₃Molecular Weight
665.73EU Commodity Code
38220090Shipping Temp
Blue IceStorage Temp
-20°CNatamycin
Pimaricin; Antibiotic A 5283; Tennecetin; Cl-12625; Mycophyt; Myprozine; Natacyn; Synogil
Pimaricin is a macrocyclic tetraene originally isolated from Streptomyces natalensis in 1957. Pimaricin exhibits broad spectrum antifungal activity against yeast and filamentous fungi by binding specifically to ergosterol to block fungal growth. Unlike the related polyenes, nystatin and filipin, pimaricin does not change the permeability of the plasma membrane. Pimaricin is used in the food industry for surface treatment of cheeses as a mould inhibitor.
Synonyms
Pimaricin; Antibiotic A 5283; Tennecetin; Cl-12625; Mycophyt; Myprozine; Natacyn; Synogil
Molecular Formula
C₃₃H₄₇NO₁₃
Apperance
Pale lemon solid
Melting Point
>200°C (dec)
Solubility
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Storage and Stability
Amber Vial, Light Sensitive, Under Inert Atmosphere. May be stored at 4°C for short-term only. For long-term storage store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Levinskas, G.J., et al.: Toxicol. Appl. Pharmacol., 8, 97 (1966), Pandey, R.C., et al.: J. Antibiot., 29, 1035 (1976), Brik, H., et al.: Anal. Profiles Drug Subs. Excip., 23, 399 (1994),USBio References
No references available