Necrosulfonamide CAS 432531-71-0

CAS Number

432531-71-0

Grade

Highly Purified

Molecular Formula

C18H15N5O6S2

Molecular Weight

461.47

EU Commodity Code

38220090

Shipping Temp

Storage Temp

4°C

N-[4-[[(3-Methoxypyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide; (E)-N-[4-[N-(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylamide

Necrosulfonamide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. RIP3 is a key signalling molecule in the programmed necrosis (necroptosis) pathway.

Melting Point

199-203ºC

Solubility

DMSO

Method for Determining Identity

Proton NMR (DMSO-d6) Spectroscopic and Mass Spectrometric Analysis

TLC Conditions

SiO2: Dichloromethane: Methanol = 9.5: 0.5; Visualized with UV and AMCS; SIngle spot, Rf=0.6

Atmosphere: Inert gas

Storage and Stability

May be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Light sensitive.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.

Source

Synthetic

Purity

~90%

Form

Supplied as a yellow solid

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

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018049 Necrosulfonamide CAS: 432531-71-0

CAS Number

Grade

Molecular Formula

Molecular Weight

EU Commodity Code

Shipping Temp

Storage Temp

N-[4-[[(3-Methoxypyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide; (E)-N-[4-[N-(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylamide

References

USBio References

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