2-Oxo-Zoniporide, HCl
N-(Aminoiminomethyl)-5-cyclopropyl-1-(1,2-dihydro-2-oxo-5-quinolinyl)-1H-pyrazole-4-carboxamide Hydrochloride
2-Oxo-Zoniporide is an metabolite of Zoniporide, a potent and selective inhibitor of human sodium-hydrogen exchanger isoform1(NHE-1) and protects against cardiac ischemia-reperfusion injury.
Synonyms
N-(Aminoiminomethyl)-5-cyclopropyl-1-(1,2-dihydro-2-oxo-5-quinolinyl)-1H-pyrazole-4-carboxamide Hydrochloride
CAS No
372078-42-7 Free Base: 372078-43-8
Molecular Formula
C17H17ClN6O2
Appearance
Pale yellow to light brown solid
Solubility
DMSO (Slightly), Methanol (Slightly, Heated)
Method for Determining Identity
Conforms to Structure Proton NMR Spectroscopic Analysis and Mass Spectrometric Analysis
TLC Conditions
SiO2; Dichloromethane: Methanol: Ammonium Hydroxide=8:2:0.1; Visualized with UV and KMnO4; Single spot, Rf=0.35
Elemental Analysis
Calculated: %C: 54.77, %H: 4.60, %N: 22.54
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months after receipt. Hygroscopic. Store under inert atmosphere.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
