Technical Data

019819
Grade
Highly Purified
Molecular Formula
C25H17D5FNO3
Molecular Weight
408.48
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
Pitavastatin-d5 Lactone
(4R,6S)-6-[(1E)-2-[2-(Cyclopropyl-d5)-4-(4-fluorophenyl)-3-quinolinyl]ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-one; [4R-[4α,6β(E)]]-6-[2-[2-(Cyclopropyl-d5)-4-|(4-fluorophenyl)-3-quinolinyl]ethenyl]tetrahydro-4-hydroxy-2H-pyran-2-one; NK 104-d5; NK 104-d5 (lactone); Nisvastatin-d5; P 872441-d5; |

A labeled metabolite of Pitavastatin. Recent studies have shown that conversion between acid and lactone forms occurs in the body, drug-drug interaction should be considered on both acid and lactone forms. The inhibitory effects of statins on CYP metabolic activities and MDR1 transporting activity were investigated using human liver microsomes and MDR1-overexpressing LLC-GA5-COL150 cells

Form
Off-White to Pale Yellow Solid
Melting Point
72-75°C
Solubility
Chloroform, Ethyl Acetate

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Wang, J., et al.: Drug Metab. Dispos., 30, 1352 (2002), Yamada, I., et al.: Xenobiotica, 33, 789 (2003), Fujino, H., et al.: Xenobiotica, 34, 961 (2004),
USBio References
No references available
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