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020321 Pyrimethamine CAS: 58-14-0

Specifications
References
CAS Number
58-14-0
Grade
Highly Purified
MDL Number
MFCD00057350
Molecular Formula
C12H13ClN4
Molecular Weight
248.71
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine; 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine; Chloridin; Chloridine; Daraprim; Khloridin; Malocide; Pirimecidan; Pirimetmin; NSC 3061; RP 4753

Dihydrofolate reductase inhibitor; generally used in combination with other antimicrobial agents. Antiprotozoal (Toxoplasma); antimalarial.

Synonyms
5-(4-Chlorophenyl)-6-ethyl-2,4-pyrimidinediamine; 2,4-Diamino-5-(4-chlorophenyl)-6-ethylpyrimidine; Chloridin; Chloridine; Daraprim; Khloridin; Malocide; Pirimecidan; Pirimetmin; NSC 3061; RP 4753
CAS Number
58-14-0
Molecular Weight
248.71
Molecular Formula
C12H13ClN4
Appearance
White solid
Purity
~97%
Melting Point
233-234°C
Solubility
Chloroform, DMSO
Method for Determining Identity
Proton NMR Spectroscopic and Mass Spectrometric Analysis
TLC Conditions
SiO2; Dichloromethane : Methanol : Ammonium Hydroxide (9 : 1 : 0.1). Visualized with UV and KMnO4.
Storage and Stability
Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards:  All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. Loutfy, M.A., et al.: Anal. Profiles Drug Subs., 12, 463 (1983). 2. Leport, C., et al.: Am. J. Med., 84, 94 (1988). 3. McIntosh, H.M., et al.: Ann. Trop. Med., Parasitol., 93, 265 (1998). 4. Plowe, C.V., et al.: Br. Med. J., 328, 545 (2004).
USBio References
No references available
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