SC-58236

020857

CAS Number

170569-86-5

Grade

Highly Purified

Molecular Formula

C16H11ClF3N3O2S

Molecular Weight

401.79

EU Commodity Code

38220090

Shipping Temp

Storage Temp

4°C

4-[5-(4-Chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide; SC-58236; SC-236;

A highly selective and potent cyclooxygenase-2 inhibitor which has been shown to induce apoptosis in gastric cells via down-regulation of Akt and then release of cytochrome c. Its anti-inflammatory effects allows for potential use in therapy for inflammatory allergic diseases.

Form

White Solid

Melting Point

146-148°C

Solubility

DMSO, Methaol

Pfizer Compound

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References

Fan, X.M. et al.: Digestion, 2, 75 (2006); Kim, S. et al.: Life Sci., 81, 863 (2007); Kim, S. et al.: J. Pharmacol. Exp. Therap., 313, 27 (2005);

USBio References

No references available

Technical Data