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020927 Sesamin CAS: 607-80-7

Specifications
References
CAS Number
607-80-7
Grade
Highly Purified
Molecular Formula
C20H18O6
Molecular Weight
354.35
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
(1S,3aR,4S,6aR)-5,5'-(Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis-1,3-benzodioxole; (+)-Sesamin; ; Fagarol; NSC 36403; Sesamin; Sezamin; d-Sesamin; 5,5'-(Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis-1,3-benzodioxole; [1S-(1α,3aα,4α,6aα)]-5,5'-(Tetrahydro-1H,3H-furo[3,4-c]furan-1,4-diyl)bis-1,3-benzodioxole; Tetrahydro-1,4-bis[3,4-(methylenedioxy)phenyl]-1H,3H-furo[3,4-c]furan; (1S,3aR,4S,6aR)-Tetrahydro-1,4-bis[3,4-(methylenedioxy)phenyl]-1H,3H-Furo[3,4-c]furan;

A lignan isolated from the bark of Fagara plants and from sesame oil. Studies show that it has has multiple functions such as cholesterol-lowering and anti-hypertensive activities. It induces the expression of the gene for aldehyde dehydrogenase, an alcohol-metabolizing enzyme suggesting it regulates the metabolism of lipids, xenobiotics, and alcohol at the mRNA level.

Melting Point
121-123°C
Solubility
Chloroform, DMSO
Method for Determining Identity
Proton NMR (DMSO-d6 and CDCl3) and MS
TLC Conditions
SiO2; Hexane : Ethyl Acetate (2:1). Visualized with UV and AMCS (single spot; Rf= 0.4).
Specific Rotation
+66.5°
Storage and Stability
Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Source
Synthetic
Purity
~98%
Form
White solid
References
Matsumura, Y. et al.: Biolog. Pharmac. Bull., 21, 469 (1998); Tsuruoka, N. et al.: Biosci. Biotechnol. Biochem., 69, 179 (2005); Ide, T. et al.: Biochim. Biophys. Acta Mol. Cell Biol. Lipids, 1534, 1 (2001);
USBio References
No references available
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