Technical Data

021939
CAS Number
2398-96-1
Grade
Highly Purified
MDL Number
MFCD00056611
Molecular Formula
C₁₉H₁₇NOS
Molecular Weight
307.41
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
Tolnaftate
N-Methyl-N-(3-methylphenyl)carbamothioic Acid O-2-Naphthalenyl Ester; Methyl(3-methylphenyl)carbamothioic Acid O-2-Naphthalenyl Ester; 2-Naphthyl N-Methyl-N-(3-tolyl)thiocarbamate; Aftate; Chinofungin; Dermoxin; Phytoderm; Pitrex; Sch 10144; Tolnaphthate; Tolsanil; Tonoftal; Tritin

Tolnaftate is used to study the mechanism of ergosterol (sterol) biosynthesis at the rate-limiting step of squalene epoxidase inhibition. Tolnaftate is clinically used to treat cutaneous infections such as athlete′s foot, jock itch, and ringworm. It also has been used as a comparator compound for antifungal efficiency studies. Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms. Tolnaftate inhibits biosynthesis of aflatoxin.

Synonyms
N-Methyl-N-(3-methylphenyl)carbamothioic Acid O-2-Naphthalenyl Ester; Methyl(3-methylphenyl)carbamothioic Acid O-2-Naphthalenyl Ester; 2-Naphthyl N-Methyl-N-(3-tolyl)thiocarbamate; Aftate; Chinofungin; Dermoxin; Phytoderm; Pitrex; Sch 10144; Tolnaphthate; Tolsanil; Tonoftal; Tritin
CAS No
2398-96-1
Molecular Formula
C₁₉H₁₇NOS
Molecular Weight
307.41
Appearance
White to off-white solid
Purity
≥98%
Melting Point
109-112°C
Solubility
Chloroform (Slightly), DMSO (Slightly)
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009)
USBio References
No references available
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