021939
CAS Number
2398-96-1Grade
Highly PurifiedMDL Number
MFCD00056611Molecular Formula
C₁₉H₁₇NOSMolecular Weight
307.41EU Commodity Code
38220090Shipping Temp
RTStorage Temp
4°CTolnaftate
N-Methyl-N-(3-methylphenyl)carbamothioic Acid O-2-Naphthalenyl Ester; Methyl(3-methylphenyl)carbamothioic Acid O-2-Naphthalenyl Ester; 2-Naphthyl N-Methyl-N-(3-tolyl)thiocarbamate; Aftate; Chinofungin; Dermoxin; Phytoderm; Pitrex; Sch 10144; Tolnaphthate; Tolsanil; Tonoftal; Tritin
Tolnaftate is used to study the mechanism of ergosterol (sterol) biosynthesis at the rate-limiting step of squalene epoxidase inhibition. Tolnaftate is clinically used to treat cutaneous infections such as athlete′s foot, jock itch, and ringworm. It also has been used as a comparator compound for antifungal efficiency studies. Tolnaftate prevents ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms. Tolnaftate inhibits biosynthesis of aflatoxin.
Synonyms
N-Methyl-N-(3-methylphenyl)carbamothioic Acid O-2-Naphthalenyl Ester; Methyl(3-methylphenyl)carbamothioic Acid O-2-Naphthalenyl Ester; 2-Naphthyl N-Methyl-N-(3-tolyl)thiocarbamate; Aftate; Chinofungin; Dermoxin; Phytoderm; Pitrex; Sch 10144; Tolnaphthate; Tolsanil; Tonoftal; Tritin
Molecular Formula
C₁₉H₁₇NOS
Appearance
White to off-white solid
Solubility
Chloroform (Slightly), DMSO (Slightly)
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Fliri, A., et al.: J. Med. Chem., 52, 8038 (2009)USBio References
No references available