Valspodar|

022718

CAS Number

121584-18-7

Grade

Highly Purified

Molecular Formula

C₆₃H₁₁₁N₁₁O₁₂

Molecular Weight

1214.62

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-oxo-6-octenoic Acid]-7-L-valine-|cyclosporin A; 6-[[R-(E)]-6,7-Didehydro-N,4-dimethyl-3-oxo-L-2-aminooctanoic acid]-7-L-valinecyclosporin A; 6-[(2S,4R,6E)-4-Methyl-2-(methylamino)-3-|oxo-6-octenoic Acid]ccyclosporin D; Amdray; PSC 833; SDZ-PSC 833; Valpodar;

Antineoplastic adjunct (chemosensitizer).

Melting Point

149-152°C

Solubility

Chloroform (Very Slightly), Methanol (Slightly)

TLC Conditions

Proton NMR (CD3OD) Spectroscopic and Mass Spectrometric Analysis

TLC Conditions

SiO2; Dichloromethane: Methanol; 9:1; Visualized with UV and AMCS; Rf=0.75

Specific Rotation

-274.6ºC (c=0.1, chloroform)

Elemental Analysis

%C:62.30, %H:9.21, %N:12.68

Storage and Stability

May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Toxicity and Hazards

All products should be handled by qualified personnel only, trained in laboratory procedures.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References

1. Boesch, D., et al.: exp. Cell Res., 196, 26 (1991), 2. Lush, R.M., et al.: J. Clin. Pharmacol., 37, 123 (1997). 3. Scott, M.G., et al.: Clin. Chem., 43, 505 (1997). 4. Advani, R., et al.: Blood, 93, 787 (1999).

USBio References

No references available

Technical Data