VX 745

022874

CAS Number

209410-46-8

Grade

Highly Purified

Molecular Formula

C19H9Cl2F2N3OS

Molecular Weight

436.26

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one;

VX 745 is a potent and selective inhibitor of p38α mitogen-activated protein (MAP) kinase. VX 745 is a potential anti-inflammatory agents. Studies suggest that VX 745 may be useful in the treatment of Werner syndrome.

Form

Pale Yellow Solid

Melting Point

259-262°C (dec.)

Solubility

Chloroform, DMSO, Methanol

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References

Haddad, J.J.: Curr. Opin. Invest. Drugs, 2, 1070 (2001); Duffy, J.P. et al.: ACS Med. Chem. Lett., 2, 758 (2011); Bagley, M.C. et al.: Pharmaceuticals, 3, 1842 (2010);

USBio References

No references available

Technical Data