031477
Grade
Affinity PurifiedGene ID
8714Gene #
ABCC3Accession Number
NP_003777.2; NP_001137542.1; O15438EU Commodity Code
30021010Shipping Temp
Blue IceStorage Temp
-20°CABCC3, ID (ABCC3, CMOAT2, MLP2, MRP3, Canalicular multispecific organic anion transporter 2, ATP-binding cassette sub-family C member 3, Multi-specific organic anion transporter D, Multidrug resistance-associated protein 3)
ABCC3, CMOAT2, MLP2, MRP3, Canalicular multispecific organic anion transporter 2, ATP-binding cassette sub-family C member 3, Multi-specific organic anion transporter D, Multidrug resistance-associated protein 3
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.
Applications
Suitable for use in Western Blot, Immunohistochemistry, Indirect Flow Cytometry and ELISA. Other applications not tested.
Recommended Dilutions
Immunohistochemistry: Formalin fixed, paraffin embedded tissues Optimal dilutions to be determined by the researcher.
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010). 2. Hoffman, A.D., et al. Protein J. 29(5):373-379(2010). 3. Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010). 4. Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010). 5. Moyer, A.M., et al. Cancer Epidemiol. Biomarkers Prev. 19(3):811-821(2010)USBio References
No references available