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036620 HLA-DPA1, CT (HLA-DPA1, HLA-DP1A, HLASB, HLA class II histocompatibility antigen, DP alpha 1 chain, DP(W3), DP(W4), HLA-SB alpha chain, MHC class II DP3-alpha, MHC class II DPA1) CAS:

Specifications
References
Swiss Prot
P20036
Grade
Affinity Purified
Gene ID
3113
Gene #
HLA-DPA1
Accession Number
NP_291032.2
EU Commodity Code
30021010
Shipping Temp
Blue Ice
Storage Temp
-20°C
HLA-DPA1, HLA-DP1A, HLASB, HLA class II histocompatibility antigen, DP alpha 1 chain, DP(W3), DP(W4), HLA-SB alpha chain, MHC class II DP3-alpha, MHC class II DPA1

HLA-DPA1 belongs to the HLA class II alpha chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta (DPB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa and its gene contains 5 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)|Varney, M.D., et al. Diabetes 59(8):2055-2062(2010)|Ovsyannikova, I.G., et al. PLoS ONE 5 (7), E11806 (2010) :|Mychaleckyj, J.C., et al. Clin Trials 7 (1 SUPPL), S75-S87 (2010) :|Pacheco, P.R., et al. BMC Res Notes 3, 134 (2010) :
USBio References
No references available
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