Technical Data

039634
Grade
Affinity Purified
Gene ID
9924
Gene #
PAN2
Accession Number
NP_055686.3; NP_001120932.1
EU Commodity Code
30021010
Shipping Temp
Blue Ice
Storage Temp
-20°C
PAN2, CT (PAN2, KIAA0710, USP52, PAB-dependent poly(A)-specific ribonuclease subunit 2, Inactive ubiquitin carboxyl-terminal hydrolase 52)
PAN2, KIAA0710, USP52, PAB-dependent poly(A)-specific ribonuclease subunit 2, Inactive ubiquitin carboxyl-terminal hydrolase 52

This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants.

Applications
Suitable for use in Western Blot, ELISA
Recommended Dilution
ELISA: 1:1,000 Western Blot: 1:100-500
Storage and Stability
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Bailey, S.D., et al. Diabetes Care (2010) In press :|Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)|Funakoshi, Y., et al. Genes Dev. 21(23):3135-3148(2007)|Ezzeddine, N., et al. Mol. Cell. Biol. 27(22):7791-7801(2007)|Yamashita, A., et al. Nat. Struct. Mol. Biol. 12(12):1054-1063(2005)
USBio References
No references available
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