044496
CAS Number
237430-03-4Grade
Highly PurifiedMDL Number
MFCD02683579Molecular Formula
C16H11N3O3Molecular Weight
293.3EU Commodity Code
38220090Shipping Temp
RTStorage Temp
4°CAlsterpaullone
Potent CDK1/cyclin B (IC50 = 35 nM) inhibitor. Anti-tumor compound Potent inhibitor of CDK2/cyclin A, CDK2/cyclin E (IC50 = 200 nM), CDK5/p25 (IC50 = 40 nM), CDK5/p35 (IC50 = 40 nM). GSK-3beta (glycogen synthase kinase-3beta) inhibitor. Apoptosis inhibitor. Apoptosis inducer. Angiogenesis inhibitor.
Synonyms
9-Nitro-7,12-dihydroindolo-[3,2-d][1]benzazepin-6(5H)-one
Molecular Formula
C16H11N3O3
Solubility
DMSO; insoluble in water or 100% ethanol.
Appearance
Supplied as a yellow to brown powder.
Storage and Stability
Store at 4°C. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
Product Reference: |●Paullones, a series of cyclin-dependent kinase inhibitors: synthesis, evaluation of CDK1/cyclin B inhibition, and in vitro antitumor activity: C. Schultz, et al.; J. Med. Chem. 42, 2909 (1999)|●Paullones are potent inhibitors of glycogen synthase kinase-3beta and cyclin-dependent kinase 5/p25: M. Leost, et al.; Eur. J. Biochem. 267, 5983 (2000)|●Intracellular Targets of Paullones. Identification following affinity purification on immobilized inhibitor: M. Knockaert, et al.; J. Biol. Chem. 277, 25493 (2002)|●The specificities of protein kinase inhibitors: an update: J. Bain, et al.; Biochem. J. 371, 199 (2003)|●Alsterpaullone, a novel cyclin-dependent kinase inhibitor, induces apoptosis by activation of caspase-9 due to perturbation in mitochondrial membrane potential: T. Lahusen, et al.; Mol Carcinog 36, 183 (2003)|●Thapsigargin-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells: T. Takadera, et al.; Neurosci. Lett. 408, 124|●Colchicine-induced apoptosis was prevented by glycogen synthase kinase-3 inhibitors in PC12 cells: T. Takadera, et al.; Cell. Mol. Neurobiol. 30, 863 (2010)|●Anti-angiogenic potential of small molecular inhibitors of cyclin dependent kinases in vitro: S. Zahler, et al.; Angiogenesis 13, 239 (2010)USBio References
No references available