BAY 58-2667 hydrochloride CAS 1240669-95-7

CAS Number

1240669-95-7

Grade

Highly Purified

Molecular Formula

C36H39NO5.HCl

Molecular Weight

602.1

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

4°C/-20°C

Nitric oxide (NO)- and heme-independent soluble guanylyl cyclase activator. Shows potent cardiovascular effects. Improves cardiopulmonary hemodynamics in patients with acute decompensated heart failure. Exhibits potent vasodilator and antiplatelet activity. Anti-aggregating agent.

CAS Number

646995-35-9

Solubility

Soluble in DSMO

Storage and Stability

Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Purity

~98% (NMR)

Form

Supplied as a white solid

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. J.P. Stasch, et al.; Br. J. Pharmacol. 136, 773 (2002). 2. P. Schmidt, et al.; Eur. J. Pharmacol. 468, 167 (2003). 3. G. Boerrigter & JC. Burnett Jr.; Cardiovasc. Drug Rev. 25, 30 (2007) (Review). 4. R. Frey, et al.; J. Clin. Pharmacol. 48, 1400 (2008). 5. T. Krieg, et al.; Eur. Heart J. 30, 1607 (2009). 6. H. Lapp, et al.; Circulation 119, 2781 (2009). 7. V. Mitrovic, et al.; Heart Fail. Rev. 14, 309 (2009) (Review). 8. J. Tamargo, et al.; Curr. Opin. Investig. Drugs 11, 1039 (2010). 9. S. Roger, et al.; Vascul. Pharmacol. 53, 281 (2010). 10. K. Götz, et al.; Circ. Res. in press (2014).

USBio References

No references available

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044595 BAY 58-2667 hydrochloride CAS: 1240669-95-7

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