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044665 Ciglitazone CAS: 74772-77-3

Specifications
References
CAS Number
74772-77-3
Grade
Highly Purified
MDL Number
MFCD00865499
Molecular Formula
C18H23NO3S
Molecular Weight
333.5
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C

Selective PPARgamma agonist (EC50=3uM). Hypoglycemic agent. Angiogenesis inhibitor. Anti-inflammatory. Apoptosis inducer.

Synonyms
(±)-5-[4-(1-Methylcyclohexylmethoxy)benzyl]-thiazolidine-2,4-dione; U-63287
CAS Number
74772-77-3
Molecular Weight
333.5
Molecular Formula
C18H23NO3S
Solubility
DMSO or 100% ethanol
Appearance
Supplied as an off-white solid.
Purity
≥99% (NMR)
Storage and Stability
Store at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones: T.M. Willson, et al.; J. Med. Chem. 39: 665 (1996). 2. Reduction of insulin resistance in obese and/or diabetic animals by 5-[4-(1-methylcyclohexylmethoxy)benzyl]- thiazolidine-2,4-dione (ADD-3878, U-63,287, ciglitazone), a new antidiabetic agent: T. Fujita, et al.; Diabetes 32: 804 (1983). 3. [[omega-(Heterocyclylamino)alkoxy]benzyl]-2,4-thiazolidinediones as potent antihyperglycemic agents:B.C. Cantello, et al.; J. Med. Chem. 37: 3977 (1994). 4. Peroxisome proliferator-activated receptor gamma ligands are potent inhibitors of angiogenesis in vitro and in vivo: X. Xin, et al.; J. Biol. Chem. 274: 9116 (1999). 5. The thiazolidinedione ciglitazone reduces bacterial outgrowth and early inflammation during Streptococcus pneumoniae pneumonia in mice: M.E. Stegenga, et al.; Crit. Care Med. 37: 614 (2009). 6. Ciglitazone, a novel inhibitor of lung apoptosis following hemorrhagic shock: R.S. Chima, et al.; Int. J. Clin. Exp. Med. 3: 1 (2010)
USBio References
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