Dynasore CAS 304448-55-3

CAS Number

304448-55-3

Grade

Highly Purified

MDL Number

MFCD11045288

Molecular Formula

C18H14N2O4 . H2O

Molecular Weight

322.39

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

4°C/-20°C

Dynamin GTPase inhibitor. Endocytosis inhibitor. Viral infection inhibitor. Destabilizes actin filaments. Inhibits entry of Trypanosoma into macrophages.

Synonyms

3-Hydroxy-naphthalene-2-carboxylic acid (3,4-dihydroxy-benzyl- idene)-hydrazide . 0.5H2O

CAS Number

304448-55-3 (free base), 1202867-00-2 (x H2O)

Molecular Weight

322.3+9.0

Molecular Formula

C18H14N2O4 . 0.5H2O

Solubility

100% ethanol (1mg/ml) or DMSO (10mg/ml); insoluble in water.

Appearance

Supplied as an off-white solid.

Purity

≥98% (NMR)

Storage and Stability

Store at 4°C. Caution: Light-sensitive. Stable for at least 2 years after receipt when stored at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Toxicity and Hazards

All products should be handled by qualified personnel only, trained in laboratory procedures.

References

1. Dynasore, a cell-permeable inhibitor of dynamin.: E. Macia, et al. ; Dev. Cell. 10, 839 (2006)|2. Use of Dynasore, the Small Molecule Inhibitor of Dynamin, in the Regulation of Endocytosis: T. Kirchhausen, et al.; Meth. Enzymol. 438, 77 (2008)|3. HPV16 and BPV1 infection can be blocked by the dynamin inhibitor dynasore: C.Y. Abban, et al.; Am. J. Ther. 15, 304 (2008)|4. Dynasore, a dynamin inhibitor, suppresses lamellipodia formation and cancer cell invasion by destabilizing actin filaments: H. Yamada, et al.; BBRC 390, 1142 (2009)|5. Dynasore, a dynamin inhibitor, inhibits Trypanosoma cruzi entry into peritoneal macrophages: E.S. Barrias, et al.; PLoS One 5, e7764 (2010)

USBio References

No references available

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044767 Dynasore CAS: 304448-55-3

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