CAS 90365-57-4

CAS Number

90365-57-4

Grade

Highly Purified

MDL Number

MFCD00151197

Molecular Formula

C17H23N3O2

Molecular Weight

301.4

EU Commodity Code

38220090

Shipping Temp

Storage Temp

4°C/-20°C

(-)-Indolactam V is a PKC activator shown to effect differentiation in embryonic stem cells leading to development of pancreatic precursors. It is active in the mouse model.

Synonym

(-)-ILV,(2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one

CAS Number

90365-57-4

Molecular Weight

301.4

Molecular Formula

C17H23N3O2

Solubility

DMSO or 100% ethanol

Appearance

Supplied as an off-white to light yellow solid.

Purity

≥97% (NMR)

Note

May contain traces of (+)-Indolactam V.

Storage and Stability

May be stored at 4°C for short-term only. Stable for 12 months after receipt when stored at -20°C. Protect from light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.

References

1. Structure-activity studies on synthetic analogues (indolactams) of the tumor promoter teleocidin: H. Fujiki, et al.; Gann 75, 866 (1984)|2. (-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells: J. Heikkilä & K. Akerman; BBRC 162, 1207 (1989)|3. (-)-Indolactam V-induced mitogenesis in human fetal/neonatal and adult T cells: lower response of neonatal cells and possible regulatory role of monocytes in protein kinase C-mediated pathways: N. Papadogiannakis; Cell. Immunol. 162, 288 (1995)|4. A small molecule that directs differentiation of human ESCs into the pancreatic lineage: S. Chen, et al.; Nat. Chem. Biol. 5, 258 (2009)

USBio References

No references available

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044953 (-)-Indolactam V CAS: 90365-57-4

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