Technical Data

044981
CAS Number
139298-40-1
Grade
Highly Purified
MDL Number
MFCD03788201
Molecular Formula
C26H29ClN2O4S•H3PO4
Molecular Weight
599
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
KN-93 (Water Soluble)
2-amino-N-(4-chlorocinnamyl)-N-methylbenzylamine

Selective Ca2+/calmodulin-dependent protein kinase II inhibitor. Insulin release inhibitor. Acid secretion inhibitor. G1 cell cycle arrest inducer. Apoptosis inducer. Ion channel inhibitor. ROS inducer. Androgen receptor inhibitor.

CAS Number
1188890-41-6, 139298-40-1 (free base)
Alternate Names
2-[N-(2-Hydroxyethyl)-N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine
Molecular Formula
C26H29ClN2O4S•H3PO4
Solubility
H2O
Molecular Weight
599
Purity
≥98% (HPLC)
Appearance
Supplied as a white to off-white solid.
Storage and Stability
Store at 4°C. Caution: Hygroscopic and light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Stable for 2 years after receipt when stored at -20°C.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells: M. Sumi, et al.; BBRC 181, 968 (1991)|2. Presence and possible involvement of Ca/calmodulin-dependent protein kinases in insulin release from the rat pancreatic beta cell: I. Niki, et al.; BBRC 191, 255 (1993)|3. Inhibition of acid secretion in gastric parietal cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-93: N. Mamiya, et al.; BBRC 195, 608 (1993)|4. G1 cell cycle arrest and apoptosis are induced in NIH 3T3 cells by KN-93, an inhibitor of CaMK-II (the multifunctional Ca2+/CaM kinase): R.M. Tombes, et al.; Cell Growth Differ. 6, 1063 (1995)|5. CaMKII-independent effects of KN93 and its inactive analog KN92: reversible inhibition of L-type calcium channels: L. Gao, et al.; BBRC 345, 1606 (2006)|6. KN-93 (2--N-(4-methoxybenzenesulfonyl)]amino-N-(4-chlorocinnamyl)-N-methylbenzylamine), a calcium/calmodulin-dependent protein kinase II inhibitor, is a direct extracellular blocker of voltage-gated potassium channels: S. Reazadeh, et al.; J. Pharmacol. Exp. Ther. 317, 292 (2006)|7. KN-93 inhibits androgen receptor activity and induces cell death irrespective of p53 and Akt status in prostate cancer: O.W. Rokhlin, et al.; Cancer Biol. Ther. 9, 224 (2010)
USBio References
No references available
United States Biological | 4 Technology Way | Salem, MA 01970
Phone 800-520-3011 | Fax 978-594-8052 | Website www.usbio.net