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045030 Malformin C CAS: 59926-78-2

Specifications
References
CAS Number
59926-78-2
Grade
Highly Purified
Molecular Formula
C23H39N5O5S2
Molecular Weight
529.7
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C/-20°C

Peptide antibiotic. Induces root curvature and malformation in plants. Antibacterial, antimalarial and antitrypanosomal. Disrupts the cell cycle at the G2 checkpoint of cancer cells, leading to sensitization of the cancer cells to anti-cancer reagents.

Malformin C is a bicyclic pentapeptide containing L-leucine, D-isoleucine, L-valine, and two D-cysteines coupled with a disulfide-bond bridge. Malformins A1 and C, originally isolated from the culture broth of Aspergillus niger FKI-2342, were found to abrogate the bleomycin-induced G2 arrest in Jurkat cells with IC50 values of 480nM and 0.9nM, respectively. Malformins may be promising candidates as anti-cancer agents.
Source
Synthetic. Originally isolated from Aspergillus niger FKI-2342.
Synonyms
5-L-Leucine-Malformin A; BRN 4896114; (-)-cyclo[D-Cys(1)-D-Cys(1)-L-Val-D-Leu-L-Leu-]
CAS Number
59926-78-2
Molecular Weight
529.70
Molecular Formula
C23H39N5O5S2
Solubility
DMSO, methanol, ethanol or chloroform. Insoluble in water.
Appearance
Supplied as a white solid.
Purity
≥95% (HPLC)
Storage and Stability
Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.
References
1. Malformin C, a new metabolite of Aspergillus niger: R.J. Anderegg, et al.; JACS 98, 3365 (1976)|2. Production and antibacterial activity of malforming C, a toxic metabolite of Aspergillus niger: B. Kobbe, et al.; Appl. Environ. Microbiol. 33, 996 (1977)|3. Fungal malformins inhibit bleomycin-induced G2 checkpoint in Jurkat cells: K. Hagimori, et al.; Biol. Pharm. Bull. 30, 1379 (2007)|4. Solid-phase synthesis and biological activity of malformin C and its derivatives: Y. Kojima, et al.; J. Antibiot. (Tokyo) 62, 681 (2009)
USBio References
No references available
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