045036
CAS Number
55266-18-7Grade
Highly PurifiedMolecular Formula
C48H28MnN4O8ClMolecular Weight
879.2EU Commodity Code
38220090Shipping Temp
RTStorage Temp
4°C/-20°CMnTBAP chloride
Manganese (III) tetrakis (4-benzoic acid)porphyrin chloride
Cell permeable superoxide dismutase (SOD) mimetic. Potent inhibitor of peroxynitrite-induced oxidative reactions (peroxynitrite scavenger), but not a scavenger of nitric oxide (NO). Neuronal apoptosis inhibitor. Protects T cells from superoxide generation, caspase-dependent DNA loss and cell death. Lipopolysaccharide-induced TNF-alpha production inhibitor, by prevention of intracellular ROS generation and subsequent inactivation of p38 MAPK and SAPK/JNK.
Synonyms
Manganese (III) tetrakis (4-benzoic acid)porphyrin chloride
Molecular Formula
C48H28MnN4O8Cl
Solubility
Dissolve at 0.1M in aqueous base, then add buffer to lower pH to pH 7.0 or higher as needed.
Appearance
Supplied as a black crystalline powder.
Storage and Stability
For short term storage, store at 4°C. Stable for 12 months after receipt when stored at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Stable Mn(III) porphyrins mimic superoxide dismutase in vitro and substitute for it in vivo: K.M. Faulkner, et al.; J. Biol. Chem. 269, 23471 (1994)|2. A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro: B.J. Day, et al.; J. Pharm. Exp. Ther. 275,1227 (1995)|3. Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger: C. Szabó, et al.; FEBS Lett. 381, 82 (1996)|4. Inhibition of neuronal apoptosis by a metalloporphyrin superoxide dismutase mimic: M. Patel; J. Neurochem. 71, 1068 (1998)|5. Reactive oxygen species regulate activation-induced T cell apoptosis: D.A. Hildeman, et al.; Immunity 10, 735 (1999)|6. MnTBAP, a synthetic metalloporphyrin, inhibits production of tumor necrosis factor-alpha in lipopolysaccharide-stimulated RAW 264.7 macrophages cells via inhibiting oxidative stress-mediating p38 and SAPK/JNK signaling: G. Tumurkhuu, et al.; FEMS Immunol. Med. Microbiol. 49, 304 (2007)USBio References
No references available