Necrostatin-5 CAS 337349-54-9

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045074 Necrostatin-5 (Nec-5, 3-p-Methoxyphenyl-5,6-tetramethylenothienopyrimidin-4-one-2-mercaptoethylcyanide) CAS: 337349-54-9

Specifications

References

CAS Number

337349-54-9

Grade

Highly Purified

Molecular Formula

C19H17N3O2S2

Molecular Weight

383.5

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

4°C

Nec-5, 3-p-Methoxyphenyl-5,6-tetramethylenothienopyrimidin-4-one-2-mercaptoethylcyanide

Necroptosis inhibitor. Indirect RIP1 kinase inhibitor.

Storage and Stability

Short-term Storage: +4°C Long-term Storage: +4°C Stable for at least 2 years after receipt when stored at +4°C.

Purity

>98% (NMR)

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

Product Reference: |●Structure-activity relationship analysis of a novel necroptosis inhibitor, Necrostatin-5: K. Wang, et al.; Bioorg. Med. Chem. Lett. 17, 1455 (2007)|●Idenfication of RIP1 kinase as a specific cellular target of necrostatins: A. Degterev, et al.; Nat. Chem. Biol. 4, 313 (2008)|●