045113
CAS Number
41443-28-1Grade
Highly PurifiedMDL Number
MFCD00792620Molecular Formula
C9H5N3O2Molecular Weight
187.2EU Commodity Code
38220090Shipping Temp
RTStorage Temp
4°C/-20°CODQ
Potent and highly selective, irreversible inhibitor of soluble guanylyl cyclase (sGC). The binding is competitive with nitric oxide (NO). Tool to elucidate the nitric oxide (NO)-cGMP pathway. Apoptosis inhibitor Inhibits growth and migration of prostate cancer cells independent of its effects on GMP levels.
Synonyms
1H-[1,2,4]Oxadiazole[4,3-a]quinoxalin-1-one
Molecular Formula
C9H5N3O2
Solubility
DMSO (≤5mg/ml), ethyl acetate or 100% ethanol (1.2mg/ml); insoluble in water
Appearance
Supplied as a white to pale yellow solid.
Storage and Stability
For short term, store at 4°C. For long term, store at -20°C in the dark. Solutions may decompose slowly. Protect from light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Nitric oxide-dependent long-term potentiation is blocked by a specific inhibitor of soluble guanylyl cyclase: C.L. Boulton, et al.; Neuroscience 69, 699 (1995)|2. Novel guanylyl cyclase inhibitor, ODQ reveals role of nitric oxide, but not of cyclic GMP in endothelin-1 secretion: F. Brunner, et al.; FEBS Lett. 376, 262 (1995)|3. Potent and selective inhibition of nitric oxide-sensitive guanylyl cyclase by 1H-oxadiazoloquinoxalin-1-one: J. Garthwaite, et al.; Mol. Pharmacol. 48, 184 (1995)|4. Characterization of 1H-oxadiazoloquinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase: A. Schrammel, et al.; Mol. Pharmacol. 50, 1 (1996)|5. Inhibition of Soluble Guanylate Cyclase by ODQ: Y. Zhao, et al.; Biochemistry 39, 10848 (2000)|6. cGMP-independent anti-tumour actions of the inhibitor of soluble guanylyl cyclase, ODQ, in prostate cancer cell lines: G. Haramis, et al.; Br. J. Pharmacol. 155, 804 (2008)USBio References
No references available