Paprotrain CAS 57046-73-8

CAS Number

57046-73-8

Grade

Highly Purified

Molecular Formula

C16H11N3

Molecular Weight

245.3

EU Commodity Code

38220090

Shipping Temp

Storage Temp

4°C/-20°C

Cell permeable kinesin-specific MKLP-2 (mitotic kinesin-like protein 2) inhibitor. Inhibits the recruitment of the chromosome passenger proteins survivin and aurora B to the central spindle during anaphase chromosome segregation.

Synonyms

(Z)-α-(3-Pyridinylmethylene)-1H-indole-3-acetonitrile

CAS Number

57046-73-8

Molecular Weight

245.3

Molecular Formula

C16H11N3

Solubility

DMSO (≥5mg/ml).

Appearance

Supplied as a yellow solid.

Purity

≥98% (NMR)

Storage and Stability

May be stored at 4°C for short-term only. Stable for 12 months after receipt when stored at -20°C. Protect from light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Toxicity and Hazards

All products should be handled by qualified personnel only, trained in laboratory procedures.

References

1. Relocation of Aurora B and Survivin from Centromeres to the Central Spindle Impaired by a Kinesin-Specific MKLP-2 Inhibitor: S. Tcherniuk, et al.; Angew. Chem. (Int'l Ed.) 49, 8228 (2010)