045136
CAS Number
18836-52-7Grade
Highly PurifiedMolecular Formula
C14H25NOMolecular Weight
223.4EU Commodity Code
38220090Shipping Temp
RTStorage Temp
-20°CPellitorine
(E,E)-N-(2-Methylpropyl) 2,4-decadienamide, BRN 1725967
Cell-permeable. A natural product isolated from the roots of Piper Nigrum. Shows larvicidal, antimycobacterial and antituberculosis activity. Modulator of the sensory neuron function to induce tingling parethesia. Tingling-inducing agent. Excellent stable model compound for sensory studies. alpha-Glucosidase inhibitor used in diabetes mellitus, cancer, infection and inflammatory research. ACAT (Acyl-CoA cholesteryl acyl transferase) inhibitor. Potential anti-cancer lead compound.
Source
Synthetic. Originally isolated from roots of Anacyclus pryrethrum and fruits of Piper nigrum.
Synonyms
(2E,4E)-N-(2-Methylpropyl)-2,4-decadienamide; BRN 1725967
Molecular Formula
C14H25NO
Appearance
Supplied as a yellow to beige solid.
Solubility
100% ethanol, methanol, DMSO or dichloromethane. Sparingly soluble in water.
Storage and Stability
Store at -20°C. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Form
Supplied as a yellow to beige solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Larvicidal activity of isobutylamides identified in Piper nigrum fruits against three mosquito species: I.K. Park, et al.; J. Agric. Food Chem. 50, 1866 (2002)|2. Chemical constituents and bioactivity of Piper sarmentosum: T. Rukachaisirikul, et al.; J. Ethnopharmacol. 93, 173 (2004)|3. Stereoselective Enzymatic Synthesis of cis-Pellitorine, a Taste Active Alkamide Naturally Occurring in Tarragon: P. J. Ley, et al.; Eur. J. Org. Chem. 2004, 5135 |4. Chemical constituents of the roots of Piper sarmentosum: P. Tuntiwachwuttikul, et al.; Chem. Pharm. Bull. (Tokyo) 54, 149 (2006)|5. HPLC assisted chemobiological standardization of alpha-glucosidase-I enzyme inhibitory constituents from Piper longum Linn - An Indian medicinal plant: S.V. Pullela, et al.; J. Ethnopharmacol. 108, 445 (2006)|6. ACAT inhibition of alkamides identified in the fruits of Piper nigrum: M.C. Rho, et al.; Phytochemistry 68, 899 (2007)|7. Pellitorine, a potential anti-cancer lead compound against HL6 and MCT-7 cell lines and microbial transformation of piperine from Piper Nigrum: G.C. Ee, et al.; Molecules 15, 2398 (2010)USBio References
No references available