Technical Data

045259
CAS Number
1132653-79-2
Grade
Highly Purified
Molecular Formula
C25H27ClN2O4
Molecular Weight
454.9
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C/-20°C
Robotnikinin (N-2-acetamide)
N--2-acetamide

Sonic hedgehog (Shh) signaling small molecule modulator. Inhibits the Shh pathway in human cell lines upstream of Smo. Targets the Shh N-terminal protein.

Synonyms
N-[(4-Chlorophenyl)methyl]-2-[(2R,6S,8E)-5,12-dioxo-2- phenyl-1-oxa-4-azacyclododec-8-en-6-yl]acetamide
CAS Number
1132653-79-2
Source
Synthetic
Molecular Weight
454.9
Molecular Formula
C25H27ClN2O4
Appearance
Supplied as a white solid.
Purity
>97% (NMR)
Solubility
DMSO, ethanol or dimethylformamide.
Storage and Stability
Store at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. A small molecule that binds Hedgehog and blocks its signaling in human cells: B.Z. Stanton, et al.; Nat. Chem. Biol. 5, 154 (2009)|2. Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog: L.F. Peng, et al.; Bioorg. Med. Chem. Lett. 19, 6319 (2009)|3. Small-molecule modulators of the Sonic Hedgehog signaling pathway: B.Z. Stanton & L.F. Peng; Mol. Biosyst. 6, 44 (2010) (Review)
USBio References
No references available
United States Biological | 4 Technology Way | Salem, MA 01970
Phone 800-520-3011 | Fax 978-594-8052 | Website www.usbio.net