Robotnikinin CAS 1132653-79-2

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045259 Robotnikinin (N-2-acetamide) CAS: 1132653-79-2

Specifications

References

CAS Number

1132653-79-2

Grade

Highly Purified

Molecular Formula

C25H27ClN2O4

Molecular Weight

454.9

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

4°C/-20°C

N--2-acetamide

Sonic hedgehog (Shh) signaling small molecule modulator. Inhibits the Shh pathway in human cell lines upstream of Smo. Targets the Shh N-terminal protein.

Synonyms

N-[(4-Chlorophenyl)methyl]-2-[(2R,6S,8E)-5,12-dioxo-2- phenyl-1-oxa-4-azacyclododec-8-en-6-yl]acetamide

CAS Number

1132653-79-2

Source

Synthetic

Molecular Weight

454.9

Molecular Formula

C25H27ClN2O4

Appearance

Supplied as a white solid.

Purity

>97% (NMR)

Solubility

DMSO, ethanol or dimethylformamide.

Storage and Stability

Store at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

References

1. A small molecule that binds Hedgehog and blocks its signaling in human cells: B.Z. Stanton, et al.; Nat. Chem. Biol. 5, 154 (2009)|2. Syntheses of aminoalcohol-derived macrocycles leading to a small-molecule binder to and inhibitor of Sonic Hedgehog: L.F. Peng, et al.; Bioorg. Med. Chem. Lett. 19, 6319 (2009)|3. Small-molecule modulators of the Sonic Hedgehog signaling pathway: B.Z. Stanton & L.F. Peng; Mol. Biosyst. 6, 44 (2010) (Review)