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145660 8-pCPT-2-O-Me-cAMP-AM (007-AM) (8-(4-Chlorophenylthio)-2'-O-methylad enosine-3',5'-cyclic monophosphate acetoxymethyl ester) CAS: 1152197-23-3

Specifications
References
CAS Number
1152197-23-3
Grade
Highly Purified
Molecular Formula
C20H21ClN5O8PS
Molecular Weight
557.9
EU Commodity Code
38220090
Shipping Temp
Dry Ice
Storage Temp
-70°C

Selective Epac activator; cAMP analog. Induces Rap activation and junction tightening in HUVECs; triggers adhesion of Jurkat-Epac1 cells to fibronectin. This product is a mixture of axial and equatorial isomers. Both isomers give 8CPT-2Me-cAMP after esterase cleavage.

Sequence
C20H21ClN5O8PS
Solubility
DMSO (~100mM)
Molecular Weight
~557.9
Storage and Stability
Aliquot to avoid repeated freezing and thawing and store at -70°C. Aliquots are stable for 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Purity
≥97% (HPLC)
Form
Supplied as a white lyophilized solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Vliem et al (2008) 8-pCPT-2'-O-Me-cAMP-AM: an improved Epac-selective cAMP analogue. Chembiochem. 9: 2052. PMID: 18633951. 2. Tsalkova et al (2012) Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc.Natl.Acad.Sci.U.S.A. 109:18613. PMID: 23091014. 3. Almahariq et al (2013) A novel EPAC-specific inhibitor suppresses pancreatic cancer cell migration and invasion. Mol.Pharmacol. 83:122. PMID: 23066090.
USBio References
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