Hexa-D-arginine CAS 673202-67-0

CAS Number

673202-67-0

Grade

Highly Purified

Molecular Formula

C36H75N25O6

Molecular Weight

954.16

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

Inhibitor of furin (Ki values are 0.106, 0.58 and 13.2um for furin, PACE4 and PC1 respectively).

Sequence

D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-NH2

Solubility

20% acetonitrile/H2O (~1mg/ml)

Molecular Weight

~954.16

Storage and Stability

Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Purity

~96% (HPLC)

Concentration

Not determined

Form

Supplied as a white lyophilized solid.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Cameron et al (2000) Polyarginines are potent furin inhibitors. J.Biol.Chem. 275:36741. PMID: 10958789. 2. Yuan et al (2012) Hexa-D-arginine treatment increases 7B2.PC2 activity in hyp-mouse osteoblasts and rescues the HYP phenotype. J.Bone Miner.Res. Epub ahead of print. PMID: 22886699.

USBio References

No references available

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145676 Hexa-D-arginine (D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-D-Arg-NH2) CAS: 673202-67-0

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