P11 CAS 848644-86-0

CAS Number

848644-86-0

Grade

Highly Purified

Molecular Formula

C30H48N12O9

Molecular Weight

720.78

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

Potent antagonist of the integrin avb3-vitronectin interaction (IC50 = 25.72nm). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.

Sequence

His-Ser-Asp-Val-His-Lys-NH2

Solubility

20% acetonitrile, 0.1% acetic acid (~1mg/ml)

Molecular Weight

~720.78

Storage and Stability

Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Purity

~97% (HPLC)

Concentration

Not determined

Form

Supplied as a white solid.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Lee et al (2004) High-throughput screening of novel peptide inhibitors of an integrin receptor from the hexapeptide library by using a protein microarray chip. J.Biomol.Screen. 9: 687. PMID: 15634795. 2. Choi et al (2010) Site-specific inhibition of integrin alpha v beta 3-vitronectin association by a ser-asp-val sequence through an Arg-Gly-Asp-binding site of the integrin. Proteomics 10:72. PMID: 19882657. 3.Bang et al (2011) Pharmacoproteomic analysis of a novel cell-permeable inhibitor of tumor-induced angiogenesis. Mol.Cell Proteomics 10:M110. PMID: 21558493.

USBio References

No references available

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145685 P11 (His-Ser-Asp-Val-His-Lys-NH2, Potent antagonist of alphavbeta3-vitronectin Interaction, Antiangiogenic) CAS: 848644-86-0

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