145691
CAS Number
136434-34-9Grade
Highly PurifiedMolecular Formula
C18H19NOS.HClMolecular Weight
333.88EU Commodity Code
38220090Shipping Temp
Blue IceStorage Temp
RTS-Duloxetine Hydrochloride (Potent 5-HT and NA Reuptake Inhibitor, Blocks Dopamine Reuptake, (+)-S-N-Methyl-3-(1-naphthyloxy)- 3-(2-thienyl)propanamine hydrochloride)
High affinity, competitive 5-HT and norepinephrine (NE) re-uptake inhibitor (Ki values are 8.5 and 45nm for 5-HT and NE reuptake respectively in cortical synaptosomes; IC50 values are 28 and 46nm for 5-HT and NE reuptake respectively in rat hippocampal slices). Also blocks dopamine reuptake (Ki=300nm in striatal synaptosomes). Exhibits antidepressant and anxiolytic effects. Orally bioavailable.
Solubility
DMSO (~100mM), H2O (~10mM) with gentle warming
Storage and Stability
Store at RT. Stable for 12 months.
Concentration
Not determined
Form
Supplied as a off-white solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Wong et al (1988) LY227942, an inhibitor of serotonin and norepinephrine uptake: biochemical pharmacology of a potential antidepressant drug. Life Sci. 43 2049. PMID: 2850421. 2. Kasamo et al (1996) Blockade of the serotonin and norepinephrine uptake processes by duloxetine: in vitro and in vivo studies in the rat brain. J.Pharmacol.Exp.Ther. 277 278. PMID: 8613930.USBio References
No references available