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145694 TC HSD 21 (5-[(3-Bromo-4-hydroxyphenyl)methyle­ne]-3-(4-methoxyphenyl)-2-thioxo-4-thiazolidinone) CAS: 330203-01-5

Specifications
References
CAS Number
330203-01-5
Grade
Highly Purified
Molecular Formula
C17H12BrNO3S2
Molecular Weight
422.32
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C

Potent 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3) inhibitor (IC50 values are 6 and 40nm at human and mouse 17beta-HSD3 respectively). Displays no activity at 17beta-HSD1, 17beta-HSD2, ERalpha, androgen receptors or glucocorticoid receptors.

Sequence
C17H12BrNO3S2
Solubility
DMSO (~100mM)
Molecular Weight
~422.32
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Purity
~99% (HPLC)
Concentration
Not determined
Form
Supplied as a yellow solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Harada et al (2012) Identification of oxazolidinediones and thiazolidinediones as potent 17β-hydroxysteroid dehydrogenase type 3 inhibitors. Bioorg.Med.Chem.Lett. 22: 504. PMID: 22137341.
USBio References
No references available
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