Technical Data

163014
CAS Number
868540-17-4
Grade
Highly Purified
Molecular Formula
C40H57N5O7
Molecular Weight
719.91
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
Carfilzomib
(αS)-α-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide; (αS)-α-[(4-Morpholinylacetyl)amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-L-phenylalaninamide; PR 171

Carfilzomib is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.

Synonyms
(αS)-α-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide; (αS)-α-[(4-Morpholinylacetyl)amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyloxiranyl]carbonyl]butyl]-L-phenylalaninamide; PR 171
CAS No
868540-17-4
Molecular Formula
C40H57N5O7
Molecular Weight
719.91
Purity
≥98% (HPLC and TLC)
Appearance
White to off-white solid
Solubility
Soluble in DMSO and DMF at 15mg/ml; soluble in ethanol at 1mg/ml with warming; slightly soluble in water.
Melting Point
204-210°C (lit)
Method of Determining Identity
Proton NMR Spectroscopic and Mass Spectrometric Analysis
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months after receipt.. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Fostier, K., et al.: Oncotargets. Therap., 5, 237 (2012). 2. Geurink, P.P., et al.: J. Med. Chem., 56, 1262 (2013). 3. McCormack, P.L., et al.: Drugs., 72, 2023 (2012)
USBio References
No references available
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