207014
CAS Number
360068-87-7, 3915-24-0 (freebase)Grade
Highly PurifiedMolecular Formula
C26H45NO•HClMolecular Weight
424.1EU Commodity Code
38220090Shipping Temp
Blue IceStorage Temp
-20°C22-NHC, Hydrochloride
22-Azacholesterol; (3β)-20S-[(3-Methylbutyl)amino]-pregn-5-en-3-ol
Aza-steroid. Hedgehog signaling inhibitor. Competes with 20(S)-OHC for access to the cysteine-rich domain in Smoothened (Smo). For control compound see 22-NHC (inactive isomer).
Synonyms
22-Azacholesterol; (3β)-20S-[(3-Methylbutyl)amino]-pregn-5-en-3-ol
CAS No
360068-87-7, 3915-24-0 (free base)
Molecular Formula
C26H45NO•HCl
Method for Determining Identity
Proton NMR
Storage and Stability
Store at 4°C. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling: D. Nedelcu, et al.; Nat. Chem. Biol. 9: 557 (2013)USBio References
No references available