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207014 22-NHC, Hydrochloride CAS: 360068-87-7, 3915-24-0 (freebase)

Specifications
References
CAS Number
360068-87-7, 3915-24-0 (freebase)
Grade
Highly Purified
Molecular Formula
C26H45NO•HCl
Molecular Weight
424.1
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
22-Azacholesterol; (3β)-20S-[(3-Methylbutyl)amino]-pregn-5-en-3-ol

Aza-steroid. Hedgehog signaling inhibitor. Competes with 20(S)-OHC for access to the cysteine-rich domain in Smoothened (Smo). For control compound see 22-NHC (inactive isomer).

Synonyms
22-Azacholesterol; (3β)-20S-[(3-Methylbutyl)amino]-pregn-5-en-3-ol
CAS No
360068-87-7, 3915-24-0 (free base)
Molecular Formula
C26H45NO•HCl
Molecular Weight
424.10
Appearance
White solid
Purity
≥98% (NMR)
Method for Determining Identity
Proton NMR
Solubility
DMSO
Storage and Stability
Store at 4°C. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
1. Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling: D. Nedelcu, et al.; Nat. Chem. Biol. 9: 557 (2013)
USBio References
No references available
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