Technical Data

207120
CAS Number
83852-56-6
Grade
Highly Purified
Molecular Formula
C27H28O9
Molecular Weight
496.5
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
Chrysomycin B (Chrysomycin M, Virenomycin M)

Antibiotic. Topoisomerase II inhibitor. Mediates a unique cross-linking reaction between DNA and histidine H3. Anti-neoplastic. Photosensitizing compound. Antitumor compound against human cell lines. Less potent than chrysomycin A.

Source
Streptomyces sp.
Synonyms
Chrysomycin M; Virenomycin M
CAS No
83852-56-6
Molecular Formula
C27H28O9
Molecular Weight
496.5
Solubility
Soluble in DMSO or dimethylformamide; slightly soluble in 100% ethanol or methanol.
Method for Determining Identity
Proton NMR
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Streptomyces sp.
Purity
≥98% (HPLC)
Form
Supplied as a yellow to greenish solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Chrysomycin: a new antibiotic substance for bacterial viruses: F. Strelitz, et al.; J. Bacteriol. 69: 280 (1955). 2. The chemistry of the antibiotics chrysomycin A and B. Antitumor activity of chrysomycin A: U. Weiss, et al.; J. Antibiot. 35: 1194 (1982). 3. Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II: A. Lorico and B.H. Long; Eur. J. Cancer 29A: 1985 (1993)
USBio References
No references available
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