Chrysomycin B CAS 83852-56-6

CAS Number

83852-56-6

Grade

Highly Purified

Molecular Formula

C27H28O9

Molecular Weight

496.5

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

Antibiotic. Topoisomerase II inhibitor. Mediates a unique cross-linking reaction between DNA and histidine H3. Anti-neoplastic. Photosensitizing compound. Antitumor compound against human cell lines. Less potent than chrysomycin A.

Source

Streptomyces sp.

Synonyms

Chrysomycin M; Virenomycin M

CAS No

83852-56-6

Molecular Formula

C27H28O9

Molecular Weight

496.5

Solubility

Soluble in DMSO or dimethylformamide; slightly soluble in 100% ethanol or methanol.

Method for Determining Identity

Proton NMR

Storage and Stability

Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Source

Streptomyces sp.

Purity

≥98% (HPLC)

Form

Supplied as a yellow to greenish solid.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Chrysomycin: a new antibiotic substance for bacterial viruses: F. Strelitz, et al.; J. Bacteriol. 69: 280 (1955). 2. The chemistry of the antibiotics chrysomycin A and B. Antitumor activity of chrysomycin A: U. Weiss, et al.; J. Antibiot. 35: 1194 (1982). 3. Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent inhibitors of human topoisomerase II: A. Lorico and B.H. Long; Eur. J. Cancer 29A: 1985 (1993)

USBio References

No references available

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207120 Chrysomycin B (Chrysomycin M, Virenomycin M) CAS: 83852-56-6

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