Concanamycin C CAS 81552-34-3

CAS Number

81552-34-3

Grade

Highly Purified

Molecular Formula

C45H74O13

Molecular Weight

823.1

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

Antibiotic. Vacuolar-type H+-ATPase inhibitor. Inhibitor of autophagic degradation by rising lysosomal pH and thus inactivating the lysosomal acid hydrolases. Anti-osteoporotic. Antiviral. Immunosuppressive. Antifungal and anti-yeast.

CAS Number

81552-34-3

Source

Streptomyces sp.

Formula

C45H74O13

Solubility

DMSO, methanol, chloroform or acetonitrile; insoluble in H2O.

Molecular Weight

823.1

Method for Determining Identity

Proton NMR

Storage and Stability

Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Source

Streptomyces sp.

Purity

≥98% (HPLC)

Form

Supplied as a white to off-white solid.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Structures of concanamycins B and C: H. Kinashi, et al.; J. Antibiot. (Tokyo) 35: 1618 (1982). 2. Isolation and characterization of concanamycins A, B and C: H. Kinashi, et al.; J. Antibiot. (Tokyo) 37: 1333 (1984). 3. Inhibitory effect of modified bafilomycins and concanamycins on P- and V-type adenosinetriphosphatases: S. Drose, et al.; Biochemistry 32: 3902 (1993). 4. Disruption of vma-1, the gene encoding the catalytic subunit of the vacuolar H(+)-ATPase, causes severe morphological changes in Neurospora crassa: E.J. Bowman, et al.; J. Biol. Chem. 275: 167 (2000). 5. Semisynthetic derivatives of concanamycin A and C, as inhibitors of V- and P-type ATPases: structure-activity investigations and developments of photoaffinity probes: S. Drose, et al.; Biochemistry 40: 2816 (2001). 6. Inhibitors of V-ATPase: old and new players: M. Huss, et al.; J. Exp. Biol. 212: 341 (2009)

USBio References

No references available

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207134 Concanamycin C (4'-O-De(aminocarbonyl)concanamycin A) (High Purity) CAS: 81552-34-3

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