Echinosporin CAS 79127-35-8

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207160 Echinosporin (NSC357683, XK 213, (1S,4aS,5S,7aS)-5-Hydroxy-8-oxo-1,4a,5,7a-tetrahydro-1,5-(epoxymethano)cyclopenta[c] pyran-3-carboxamide) CAS: 79127-35-8

Specifications

References

CAS Number

79127-35-8

Grade

Highly Purified

Molecular Formula

C10H9NO5

Molecular Weight

223.2

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

Antibiotic. Cell cycle inhibitor at the G(2)/M phase. Antitumor compound. Apoptosis inducer.

CAS Number

79127-35-8

Source

Streptomyces sp.

Formula

C10H9NO5

Solubility

H2O, methanol or dimethylformamide.

Molecular Weight

223.2

Method for Determining Identity

Proton NMR

Purity

≥98% (HPLC)

Appearance

Supplied as a white to off-white solid.

Storage and Stability

Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

References

1. A new antibiotic echinosporin (XK-213) - producing organism, isolation and characterization: T. Sato, et al.; J. Antibiot. 35: 266 (1982). 2. Antitumor activity of echinosporin: M. Morimoto and R. Imai; J. Antibiot. 38: 490 (1985) 3. Approaches to the total synthesis of the antitumor antibiotic echinosporin: M. A. Kinsella; J. Org. Chem. 55: 105 (1990) 4. Applications of an asymmetric [2 + 2]-photocycloaddition. Total synthesis of (-)-echinosporin. Construction of an advanced 11-deoxyprostaglandin intermediate: A. B. Smith; J. Am. Chem. Soc. 114: 2567 (1992) 5. Biosynthesis of the antibiotic echinosporin by a novel branch of the shikimate pathway: A. Dubeler; Eur. J. Org. Chem. 2002: 983 (2002). 6. Echinosporins as new cell cycle inhibitors and apoptosis inducers from marine-derived Streptomyces albo- griseolus: C.B. Cui, et al.; Fitoterapia 78: 238 (2007).