FTY720 Hydrochloride CAS 162359-56-0

CAS Number

162359-56-0

Grade

Highly Purified

Molecular Formula

C19H33NO2. HCl

Molecular Weight

307.4365

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

Cell permeable immunosuppressor displaying lymphocyte sequestration properties and used for treatment in multiple sclerosis. Potent sphingosine 1-phosphate (S1P) receptor (S1P1, S1P3, S1P4, and S1P5) agonist when phosphorylated by sphingosine kinase. Sphingosine transporter Abcb1 and leukotriene C4 transporter Abcc1 activity enhancer. Cytosolic phospholipase A2 inhibitor, independent of sphingosine 1-phosphate receptors. Autophagy inducer. Apoptosis inducer.

Source

Synthetic analog of ISP-1, isolated from Isaria sinclairii

Formula

C19H33NO2 . HCl

Solubility

DMSO, ethanol or DMF

Molecular Weight

~307.4, 36.5

Storage and Stability

Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with DMSO, ethanol or DMF. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Source

Isaria sinclairii

Purity

≥98%

Concentration

Not determined

Form

Supplied as a white solid.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. FTY720: Altered lymphocyte traffic results in allograft protection: V. Brinkmann, et al.; Transplantation 72: 764 (2001) 2. The immune modulator FTY720 targets sphingosine 1-phosphate receptors: V. Brinkmann, et al.; J. Biol. Chem. 277: 21453 (2002) 3. FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes: S.M. Honig, et al.; J. Clin. Invest. 111: 627 (2003) 4. Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1: M. Matloubian, et al.; Nature 427: 355 (2004) 5. The immunosuppressant drug FTY720 inhibits cytosolic phospholipase A2 independently of sphingosine-1-phosphate receptors: S.G. Payne, et al.; Blood 109: 1077 (2007) 6. Fingolimod (FTY720): a recently approved multiple sclerosis drug based on a fungal secondary metabolite: C.R. Strader, et al.; J. Nat. Prod. 74: 900 (2011) 7. Autophagy induced by FTY720 promotes apoptosis in U266 cells: A. Liao, et al.; Eur. J. Pharm. Sci. 45: 600 (2012). 8. Induction of brain tumor stem cell apoptosis by FTY720: a potential therapeutic agent for glioblastoma: A. Estrada-Bernal, et al.; Neuro Oncol. 14: 405 (2012)

USBio References

No references available

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207189 FTY720 Hydrochloride (Gilenya, 2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propanediol . HCl, Fingolimod) CAS: 162359-56-0

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