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207219 Heliquinomycin (Rubymycin, NSC 702208) CAS: 178182-49-5

Specifications
References
CAS Number
178182-49-5
Grade
Purified
Molecular Formula
C33H30O17
Molecular Weight
698.6
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C

Antibiotic. DNA helicase inhibitor. Inhibits the DNA helicase activity of the human minichromosome maintenance (MCM) 4/6/7 complex. Topoisomerase I and II inhibitor (weaker than DNA helicase). DNA and RNA synthesis inhibitor in cell culture. Does not inhibit protein synthesis. Induces cell cycle arrest. Anticancer compound. Antibacterial against Gram-positive bacteria.

CAS No.
178182-49-5
Source
Streptomyces sp. MJ929-SF2.
Molecular Formula
C33H30O17
Solubility
DMSO, ethanol, chloroform or ethyl acetate. Insoluble in H2O or n-hexane.
Molecular Weight
698.6
Appearance
Red powder
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile buffer or ddH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 6 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Streptomyces sp. MJ929-SF2.
Purity
≥80% (HPLC)
Concentration
Not determined
Form
Supplied as a red powder.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 I. Taxonomy, production, isolation, physico-chemical properties and biological activities: M. Chino, et al.; J. Antibiot. 49: 752 (1996). 2. Effect of a novel antibiotic, heliquinomycin, on DNA helicase and cell growth: M. Chino, et al.; J. Antibiot. 51: 480 (1998). 3. Effect of heliquinomycin on the activity of human minichromosome maintenance 4/6/7 helicase: Y. Ishimi, et al.; FEBS J. 276: 3382 (2009). 4. Interaction of heliquinomycin with single-stranded DNA inhibits MCM4/6/7 helicase: T. Sugiyama, et al.; J. Biochem. 151: 129 (2012).
USBio References
No references available
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