Technical Data

207359
CAS Number
82508-31-4
Grade
Highly Purified
Molecular Formula
C₂₃H₂₈O₈
Molecular Weight
432.5
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
4°C
Pseudolaric Acid B
NSC 615488; O-Acetylpseudolaric Acid C; Pseudolaric Acid B; Pseudolarix Acid B;|[3R-[3α(1E,3E),4α,4aα,9aα]]-4a-(Acetyloxy)-3-(4-carboxy-1,3-pentadienyl)-3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-1H-4,9a-Ethanocyclohepta[c]pyran-7-carboxylic Acid 7-Methyl Ester;|(3R,4S,4aS,9aR)-4a-(Acetyloxy)-3-[(1E,3E)-4-carboxy-1,3-pentadienyl]-3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-1H-4,9a-Ethanocyclohepta[c]pyran-7-carboxylic Acid 7-Methyl Ester

Antifungal and antifertility compound. Antitumor compound. PPARalpha signaling agonist. Angiogenesis inhibitor. Apoptosis and autophagy inducer. Microtubule-destabilizing agent. Anti-inflammatory. Inhibits NF-kappaB and p38 signaling. Immunosuppressive.

Synonyms
NSC 615488; O-Acetylpseudolaric Acid C; Pseudolaric Acid B; Pseudolarix Acid B; [3R-[3α(1E,3E),4α,4aα,9aα]]-4a-(Acetyloxy)-3-(4-carboxy-1,3-pentadienyl)-3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-1H-4,9a-Ethanocyclohepta[c]pyran-7-carboxylic Acid 7-Methyl Ester; (3R,4S,4aS,9aR)-4a-(Acetyloxy)-3-[(1E,3E)-4-carboxy-1,3-pentadienyl]-3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-1H-4,9a-Ethanocyclohepta[c]pyran-7-carboxylic Acid 7-Methyl Ester
CAS Mo
82508-31-4
Source
Pseudolarix kaempferi
Formula
C₂₃H₂₈O₈
Solubility
DMSO, ethanol, methanol or chloroform
Molecular Weight
432.5
Appearance
White to off-white solid.
Purity
≥98% (HPLC)
Storage and Stability
Store at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Pseudolaric Acids from Pseudolarix kaempferi: B.N. Zhou, et al.; Planta Med. 47: 35 (1983). 2. The cytotoxic principles of Pseudolarix kaempferi: pseudolaric acid-A and -B and related derivatives: D.J. Pan, et al.; Planta Med. 56: 383 (1990) 3. Antifungal evaluation of pseudolaric acid B, a major constituent of Pseudolarix kaempferi: E. Li, et al.; J. Nat. Prod. 58: 57 (1995). 4. Pseudolaric acid analogs as a new class of peroxisome proliferator-activated receptor agonists: M.S. Jardat, et al.; Planta Med. 68: 667 (2002). 5. Pseudolarix acid B inhibits angiogenesis by antagonizing the vascular endothelial growth factor-mediated anti-apoptotic effect: W.F. Tan, et al.; Eur. J. Pharmacol. 499: 219 (2004). 6. Pseudolaric acid B inhibits angiogenesis and reduces hypoxia-inducible factor1 alpha by promoting proteasome- mediated degradation: M.H. Li, et al.; Clin. Cancer Res. 10: 8266 (2004). 7. Pseudolaric acid B induces apoptosis through p53 and Bax/Bcl-2 pathways in human melanoma A375-S2 cells: X.F. Gong, et al.; Arch. Pharm. Res. 28: 68 (2005). 8. Pseudolaric acid B , a novel microtubule-destabilizing agent that circumvents multidrug resistance phenotype and exhibits antitumor activity in vivo: V.K. Wong, et al.; Clin. Cancer Res. 11: 6002 (2005). 9. Effect of pseudolaric acid B on gastric cancer cells: inhibition of proliferation and induction of apoptosis: K.S. Li, et al.; World J. Gastroenterol. 11: 7555 (2005). 10. Pseudolarix acid B, a new tubulin-binding agent, inhibits angiogenesis by interacting with a novel binding site on tubulin: Y.G. Tong, et al.; Mol. Pharmacol. 69: 1226 (2006)
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