Q-VE-OPh CAS

Grade

Highly Purified

Molecular Formula

C27H27F2N3O6

Molecular Weight

527.5

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

[Q-Val-Glu-OPh; pan-Caspase Inhibitor (Negative Control); N-(2-|Quinolyl)-L-valyl-L-glutamyl-(2,6-difluorophenoxy) methylketone]

Cell permeable, non-toxic negative control for the caspase inhibitor Q-VD-OPh (207366). Stable in aqueous environment. Several folds less inhibitory activity than Q-VD-OPh. Perfect for both in vitro and in vivo studies.

Synonyms

Q-Val-Glu-OPh; pan-Caspase Inhibitor (Negative Control); N-(2-Quinolyl)-L-valyl-L-glutamyl-(2,6-difluorophenoxy) methylketone

Source

Synthetic

Molecular Formula

C27H27F2N3O6

Molecular Weight

527.5

Sequence

Q-Val-Glu-OPh

Solubility

DMSO

Appearance

Supplied as a white solid.

Purity

≥95% (TLC)

Storage and Stability

May be stored at 4°C for short-term only. Keep cool and dry. Stable for 12 months after receipt when stored at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Toxicity and Hazards

All products should be handled by qualified personnel only, trained in laboratory procedures.

References

1. Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties: T.M. Caserta, et al.; Apoptosis 8: 345 (2003). 2. The role of caspases in Alzheimer's disease; potential novel therapeutic opportunities: T.T. Rohn; Apoptosis 15: 1403 (2010). 3. Q-VE-OPh, a Negative Control for O-Phenoxy-Conjugated Caspase Inhibitors: B. Southerland, et al.; J. Cell Death 3: 33 (2010). 4. The pan-caspase inhibitor Q-VD-OPh has anti-leukemia effects and can interact with vitamin D analogs to increase HPK1 signaling in AML cells: X. Chen-Deutsch, et al.; Leuk. Res. 36: 884 (2012)

USBio References

No references available

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207367 Q-VE-OPh (Negative Control) CAS:

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[Q-Val-Glu-OPh; pan-Caspase Inhibitor (Negative Control); N-(2-|Quinolyl)-L-valyl-L-glutamyl-(2,6-difluorophenoxy) methylketone]

References

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